Dermatology

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Pruritus

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Pruritus Localized pruritus Generalized pruritus NRS Pruritus

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Generalized pruritus

Generalized pruritus can occur in association with multiple conditions, such as dermatologic disorders, liver or kidney dysfunction, malignancy, systemic rheumatic disease, infections, or drug reaction.

Metabolic/endocrine disorders

• Hyperparathyroidism
• Iron deficiency
• Diabetes mellitus
• Alcoholism
• Hyper- and hypothyroidism
• Carcinoid syndrome

Infectious diseases

• HIV
• Helminth and parasitic infection
• Viral hepatitis (HVB, HVC)
• Scabies
• Dermatophytosis
• Onchocerciasis
• Varicella

Systemic diseases

• Primary biliary cholangitis
• Primary biliary cirrhosis
• Infectious hepatitis
• Chronic kidney failure

Autoimmune disorders

• Dermatomyositis
• Systemic sclerosis
• Sjögren syndrome

Hematologic diseases

• Polycythemia vera
• Essential thrombosis
• Hodgkin and non-Hodgkin lymphoma
• Ferropenic anemia
• Mastocytosis
• Multiple myeloma

Neurological disorders

• Multiple sclerosis
• Brain tumors
• Notalgia paresthetica
• Brachioradial pruritis
• Postherpetic neuralgia
• Small fiber neuropathy

Psychiatric disorders

• Depression
• Anxiety
• Delusional disorders
• Anorexia nervosa

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